Amyloid precursor protein concentrated on the surface of neurons.
APP PROTEIN
"Amyloid plaques formed after deposition can be found in the brains of Alzheimer's patients."
Amyloid precursor protein (APP) is a membrane intrinsic protein expressed in many tissues and concentrated in synapses of neurons.
App autosomal dominant changes lead to hereditary early-onset Alzheimer's disease, and the result may also be changes in protein hydrolysis process.
App can be decomposed by α -, β -, γ - proteases.
The continuous action of β - protease and γ - protease can make app be decomposed to produce a β.
A β can lead to the formation of senile plaques and apoptosis of nerve cells in the brain.