Two main neuropathological features of Alzheimer's disease

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  Senile plaques (SPs)

  Plaques are mostly composed of dense and insoluble amyloid beta peptides and cell derivatives, which usually accumulate around neurons.

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  Neurofibrillary tangles (NFTs)

  Neurofibrillary tangles are usually composed of microtubule associated protein tau, which is hyperphosphorylated and accumulated in cells.

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