It is hydrolyzed from β - amyloid precursor protein (APP) and secreted by cells. It has a strong neurotoxic effect after the accumulation of cell matrix.
BETA PROTEIN
"The deposition of a β is not only related to the degeneration of neurons, but also can activate a series of pathological events."
The neurotoxic effect of Aβ.
The toxic effect of a β on nervous system is amyloidosis of vascular wall, which directly leads to arteriosclerosis, poor elasticity, even easy rupture or thrombosis, and also induces premature apoptosis of nerve cells.
Aβ promotes the deposition of perivascular fibers, leading to amyloid angiopathy.
The deposition of a β reduced the adhesion of smooth muscle cells to the basement membrane, and the middle layer of the vessel was replaced by a β, resulting in the degeneration of smooth muscle cells.
The expression of fibroblast growth factor-2 was decreased.